This book provides an up-to-date review of the general principles and techniques of confirmatory adaptive designs, a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop a trial prematurely under control of the Type I error rate.
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In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection, or a selection of a pre-specified sub-population [...] The book describes adaptive design methodology at an elementary level, while also considering design and planning issues. It also looks at methods for analyzing an adaptively planned trial, such as estimation methods and methods for determining an overall p-value [...]. (Estratto dal sito dell'editore)
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*Group sequential and confirmatory adaptive designs in clinical trials / Gernot Wassmer, Werner Brannath. - 2. ed. - Cham : Springer, 2025. - 1 testo elettronico (xxiii, 410 p. : ill.)
